Mass Spectrometry in Medicinal Chemistry

This first overview of mass spectrometry-based pharmaceutical analysis is the key to improved high-throughput drug screening, rational drug design and analysis of multiple ligand-target interactions. The ready reference opens with a general introduction to the use of mass spectrometry in pharmaceutical screening, followed by a detailed description of recently developed analytical systems for use in the pharmaceutical laboratory.<br> Applications range from simple binding assays to complex screens of biological activity and systems containing multiple targets or ligands — all highly relevant techniques in the early stages in drug discovery, from target characterization to hit and lead finding.