Drug Design of Zinc-Enzyme Inhibitors

<b>Brings together functional and structural informationrelevant to the design of drugs targeting zinc enzymes</b> <p>The second most abundant transition element in living organisms, zinc spans all areas of metabolism, with zinc-containing proteins offering both established and potential drug targets. <i>Drug Design of Zinc-Enzyme Inhibitors</i> brings together functional and structural information relevant to these zinc-containing targets. With up-to-date overviews of the latest developments field, this unique and comprehensive text enables readers to understand zinc enzymes and evaluate them in a drug design context.</p> <p>With contributions from the leaders of today’s research, <i>Drug Design of Zinc-Enzyme Inhibitors</i> covers such key topics as:</p> <ul> <li> <p>Major drug targets like carbonic anhydrases, matrix metalloproteinases, bacterial proteases, angiotensin-converting enzyme, histone deacetylase, and APOBEC3G</p> </li> <li> <p>Roles of recently discovered zinc-containing isozymes in cancer, obesity, epilepsy, pain management, malaria, and other conditions</p> </li> <li> <p>Cross reactivity of zinc-enzyme inhibitors and activators</p> </li> <li> <p>The extensive use of X-ray crystallography and QSAR studies for understanding zinc-containing proteins</p> </li> <li> <p>Clinical applications</p> </li> </ul> <p>An essential resource for the discovery and development of new drug molecules, <i>Drug Design of Zinc-Enzyme Inhibitors</i> gives researchers, professionals, students, and academics the foundation to understand and work with zinc enzyme inhibitors and activators.</p>