Diversity-Oriented Synthesis

<p><b>Discover an enhanced synthetic approach to developing and screening chemical compound libraries</b></p> <p>Diversity-oriented synthesis is a new paradigm for developing large collections of structurally diverse small molecules as probes to investigate biological pathways. This book presents the most effective methods in diversity-oriented synthesis for creating small molecule collections. It offers tested and proven strategies for developing diversity-oriented synthetic libraries and screening methods for identifying ligands. Lastly, it explores some promising new applications based on diversity-oriented synthesis that have the potential to dramatically advance studies in drug discovery and chemical biology.</p> <p><i>Diversity-Oriented Synthesis</i> begins with an introductory chapter that explores the basics, including a discussion of the relationship between diversity-oriented synthesis and classic combinatorial chemistry. Divided into four parts, the book:</p> <ul> <li>Offers key chemical methods for the generation of small molecules using diversity-oriented principles, including peptidomimetics and macrocycles</li> <li>Expands on the concept of diversity-oriented synthesis by describing chemical libraries</li> <li>Provides modern approaches to screening diversity-oriented synthetic libraries, including high-throughput and high-content screening, small molecule microarrays, and smart screening assays</li> <li>Presents the applications of diversity-oriented synthetic libraries and small molecules in drug discovery and chemical biology, reporting the results of key studies and forecasting the role of diversity-oriented synthesis in future biomedical research</li> </ul> <p>This book has been written and edited by leading international experts in organic synthesis and its applications. Their contributions are based on a thorough review of the current literature as well as their own firsthand experience developing synthetic methods and applications.</p> <p>Clearly written and extensively referenced, <i>Diversity-Oriented Synthesis</i> introduces novices to this highly promising field of research and serves as a springboard for experts to advance their own research studies and develop new applications.</p>