Mass Spectrometry-Based Chemical Proteomics

<p><b>PROVIDES STRATEGIES AND CONCEPTS FOR UNDERSTANDING CHEMICAL PROTEOMICS, AND ANALYZING PROTEIN FUNCTIONS, MODIFICATIONS, AND INTERACTIONS—EMPHASIZING MASS SPECTROMETRY THROUGHOUT</b></p> <p>Covering mass spectrometry for chemical proteomics, this book helps readers understand analytical strategies behind protein functions, their modifications and interactions, and applications in drug discovery. It provides a basic overview and presents concepts in chemical proteomics through three angles: Strategies, Technical Advances, and Applications. Chapters cover those many technical advances and applications in drug discovery, from target identification to validation and potential treatments.</p> <p>The first section of <i>Mass Spectrometry-Based Chemical Proteomics</i> starts by reviewing basic methods and recent advances in mass spectrometry for proteomics, including shotgun proteomics, quantitative proteomics, and data analyses. The next section covers a variety of techniques and strategies coupling chemical probes to MS-based proteomics to provide functional insights into the proteome. In the last section, it focuses on using chemical strategies to study protein post-translational modifications and high-order structures.</p> <ul> <li>Summarizes chemical proteomics, up-to-date concepts, analysis, and target validation</li> <li>Covers fundamentals and strategies, including the profiling of enzyme activities and protein-drug interactions</li> <li>Explains technical advances in the field and describes on shotgun proteomics, quantitative proteomics, and corresponding methods of software and database usage for proteomics</li> <li>Includes a wide variety of applications in drug discovery, from kinase inhibitors and intracellular drug targets to the chemoproteomics analysis of natural products</li> <li>Addresses an important tool in small molecule drug discovery, appealing to both academia and the pharmaceutical industry</li> </ul> <p><i>Mass Spectrometry-Based Chemical Proteomics</i> is an excellent source of information for readers in both academia and industry in a variety of fields, including pharmaceutical sciences, drug discovery, molecular biology, bioinformatics, and analytical sciences.</p>