Reagents for Silicon-Mediated Organic Synthesis

Over the last three decades the importance of organosilicon chemistry has greatly increased because it has opened a number of new synthetic strategies. Silicon reagents are usually low-cost, versatile and allow a wide range of reactions. This is the first Handbook to compile essential Silicon containing reagents and makes use of the leading reagent database <i>e-EROS.</i> Another hot volume in the series <i>Handbooks of Reagents for Organic Synthesis</i>, this is a must-have resource for all synthetic chemists working in drug development and medicinal chemistry. <p>For the selection the Editor focussed on three key synthetic approaches with the greatest impact:</p> <p>1. Use of silicon as a ‘temporary tether’ by unifying a reactive pair of functional groups and taking advantage of their template-biased intramolecular cyclization.</p> <p>2. The specific use of the silane functionality as a hetero <i>t-</i>butyl group, often colloquially referred to as the use of silicon as a ‘fat proton’.</p> <p>3. The use of the <i>Brook rearrangement</i> as an ‘anion relay stratagem’.</p> <p>A new feature in this Handbook is the reagent finder, an alphabetically organized lookup table arranged by organic functionality and specific structure of the silicon atom to which it is bound.</p>