Metabolism of Drugs and Other Xenobiotics

A practice-oriented desktop reference for medical professionals, toxicologists and pharmaceutical researchers, this handbook provides<br> systematic coverage of the metabolic pathways of all major classes of xenobiotics in the human body. The first part comprehensively reviews<br> the main enzyme systems involved in biotransformation and how they are orchestrated in the body, while parts two to four cover the three<br> main classes of xenobiotics: drugs, natural products, environmental pollutants. The part on drugs includes more than 300 substances from<br> five major therapeutic groups (central nervous system, cardiovascular system, cancer, infection, and pain) as well as most drugs of abuse<br> <br> including nicotine, alcohol and “designer” drugs. Selected, well-documented case studies from the most important xenobiotics classes illustrate general principles of metabolism, making this equally useful for teaching courses on pharmacology, drug metabolism or molecular<br> toxicology.<br> Of particular interest, and unique to this volume is the inclusion of a wide range of additional xenobiotic compounds, including food supplements, herbal preparations, and agrochemicals.