Oral Drug Delivery for Modified Release Formulations

<p><b>Provides&nbsp;pharmaceutical development&nbsp;scientists&nbsp;with a&nbsp;detailed&nbsp;reference guide for the development of MR formulations&nbsp;</b></p> <p><i>Oral Drug Delivery for Modified Release Formulations</i>&nbsp;is&nbsp;an up-to-date review of&nbsp;the key&nbsp;aspects of oral absorption from modified-release (MR)&nbsp;dosage forms.&nbsp;This edited volume provides&nbsp;in-depth coverage of&nbsp;the physiological&nbsp;factors&nbsp;that influence&nbsp;drug release&nbsp;and&nbsp;of&nbsp;the design and evaluation of&nbsp;MR&nbsp;formulations.&nbsp;</p> <p>Divided into three&nbsp;sections,&nbsp;the&nbsp;book&nbsp;begins&nbsp;by&nbsp;describing&nbsp;the gastrointestinal tract (GIT)&nbsp;and&nbsp;detailing&nbsp;the&nbsp;conditions&nbsp;and&nbsp;absorption processes&nbsp;occurring in the GIT that determine a formulation&rsquo;s&nbsp;oral bioavailability. The second section&nbsp;explores&nbsp;the&nbsp;design of modified release formulations,&nbsp;covering&nbsp;early&nbsp;drug substance testing,&nbsp;the biopharmaceutics classification system,&nbsp;an array of&nbsp;formulation technologies that can be&nbsp;used&nbsp;for MR&nbsp;dosage&nbsp;forms, and&nbsp;more.&nbsp;The final section focuses on in vitro, in silico,&nbsp;and in vivo evaluation and regulatory considerations for MR formulations.&nbsp;Topics include&nbsp;biorelevant dissolution testing,&nbsp;preclinical evaluation, and&nbsp;physiologically-based&nbsp;pharmacokinetic modelling (PBPK)&nbsp;of&nbsp;in vivo behaviour.&nbsp;Featuring contributions from leading researchers&nbsp;with expertise&nbsp;in&nbsp;the different aspects of MR formulations, this&nbsp;volume:&nbsp;&nbsp;</p> <ul> <li>Provides authoritative coverage of physiology, physicochemical determinants, and in-vitro in-vivo correlation (IVIVC)&nbsp;</li> <li>Explains&nbsp;the&nbsp;different&nbsp;types of MR&nbsp;formulations&nbsp;and&nbsp;defines&nbsp;the&nbsp;key&nbsp;terms used in the field&nbsp;</li> <li>Discusses the present status of MR&nbsp;technologies&nbsp;and&nbsp;identifies&nbsp;current gaps in research&nbsp;&nbsp;</li> <li>Includes&nbsp;a summary of regulatory guidelines from both&nbsp;the&nbsp;US and&nbsp;the&nbsp;EU&nbsp;</li> <li>Shares&nbsp;industrial experiences and perspectives on the evaluation of MR dosage formulations&nbsp;</li> </ul> <p><i>Oral Drug Delivery for Modified Release Formulations</i>&nbsp;is&nbsp;an&nbsp;invaluable reference and guide for researchers, industrial scientists, and graduate students in general areas of drug delivery including pharmaceutics, pharmaceutical sciences, biomedical engineering, polymer and materials science, and chemical and biochemical engineering.&nbsp;</p>