A Handbook for DNA-Encoded Chemistry

<p>This book comprehensively describes the development and practice of DNA-encoded library synthesis technology. Together, the chapters detail an approach to drug discovery that offers an attractive addition to the portfolio of existing hit generation technologies such as high-throughput screening, structure-based drug discovery and fragment-based screening. The book:</p> <ul type=”disc”> <li class=”MsoNormal” style=”text-align: left; margin: 0in 0in 12pt; color: black; mso-margin-top-alt: auto; mso-margin-bottom-alt: auto; mso-list: l0 level1 lfo1; tab-stops: list .5in;”>Provides a valuable guide for understanding and applying DNA-encoded combinatorial chemistry</li> <li class=”MsoNormal” style=”text-align: left; margin: 0in 0in 12pt; color: black; mso-margin-top-alt: auto; mso-margin-bottom-alt: auto; mso-list: l0 level1 lfo1; tab-stops: list .5in;”>Helps chemists generate and screen novel chemical libraries of large size and quality</li> <li class=”MsoNormal” style=”text-align: left; margin: 0in 0in 12pt; color: black; mso-margin-top-alt: auto; mso-margin-bottom-alt: auto; mso-list: l0 level1 lfo1; tab-stops: list .5in;”>Bridges interdisciplinary areas of DNA-encoded combinatorial chemistry – synthetic and analytical chemistry, molecular biology, informatics, and biochemistry</li> <li class=”MsoNormal” style=”text-align: left; margin: 0in 0in 12pt; color: black; mso-margin-top-alt: auto; mso-margin-bottom-alt: auto; mso-list: l0 level1 lfo1; tab-stops: list .5in;”>Shows medicinal and pharmaceutical chemists how to efficiently broaden available “chemical space” for drug discovery</li> <li class=”MsoNormal” style=”text-align: left; margin: 0in 0in 12pt; color: black; mso-margin-top-alt: auto; mso-margin-bottom-alt: auto; mso-list: l0 level1 lfo1; tab-stops: list .5in;”>Provides expert and up-to-date summary of reported literature for DNA-encoded and DNA-directed chemistry technology and methods</li> </ul>