Blood-Brain Barrier in Drug Discovery

<p>Focused on central nervous system (CNS) drug discovery efforts, this book educates drug researchers about the blood-brain barrier (BBB) so they can affect important improvements in one of the most significant – and most challenging – areas of drug discovery.</p> <p>• Written by world experts to provide practical solutions to increase brain penetration or minimize CNS side-effects<br /> • Reviews state-of-the-art in silico, in vitro, and in vivo tools to assess brain penetration and advanced CNS drug delivery strategies<br /> • Covers BBB physiology, medicinal chemistry design principles, free drug hypothesis for the BBB, and transport mechanisms including passive diffusion, uptake/efflux transporters, and receptor-mediated processes<br /> • Highlights the advances in modelling BBB pharmacokinetics and dynamics relationships (PK/PD) and physiologically-based pharmacokinetics (PBPK)<br /> • Discusses case studies of successful CNS and non-CNS drugs, lessons learned and paths to the market</p>