Drug Transporters


Molecular Characterization and Role in Drug Disposition

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<i>Drug Transporters: Molecular Characterization and Role in Drug Disposition</i> provides in-depth analysis of the conceptual evolution and technical development of drug transporters. Contributions by an international panel of leading researchers address advances in transporters as drug targets, membrane transporters in pediatric pharmacotherapy, the impact of transporters on drug efficacy and safety, the development of sophisticated model systems and sensitive assay methods, and more. Divided into two parts, the book first provides a thorough overview of relevant drug transporters before detailing the principles of drug transport and associated techniques.<br /><br />The updated and expanded third edition includes new chapters on in vitro-in vivo scale-up of drug transport activities, the ontogeny of drug transporters, the application of physiologically-based pharmacokinetic and pharmacodynamic modeling, and the use of transporters as therapeutic targets for diseases.<br /><br /> <ul> <li>Reflects the current state of the field and offers perspectives on future direction</li> <li>Covers basic knowledge, clinical outcomes, and emerging discoveries in transporter science</li> <li>Provides up-to-date information on drug transporter families, mechanisms, and clinical implications</li> <li>Includes extensive references and numerous figures and tables throughout</li> </ul> <br />Accessible for novices while offering sufficient depth for more experienced researchers, <i>Drug Transporters: Molecular Characterization and Role in Drug Disposition, Third Edition</i> is an excellent textbook for pharmacological or physiological science courses in drug/membrane transport, and an invaluable reference for academic or industrial scientists working in the transporter field and related areas of drug metabolism, pharmacokinetics, and pharmacodynamics.