Enzyme Inhibition in Drug Discovery and Development

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The Good and the Bad

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ISBN: 9780470281741 Category:

The science and applied approaches of enzyme inhibition in drug discovery and development <p>Offering a unique approach that includes both the pharmacologic and pharmaco-kinetic aspects of enzyme inhibition, <i>Enzyme Inhibition in Drug Discovery and Development</i> examines the scientific concepts and experimental approaches related to enzyme inhibition as applied in drug discovery and drug development.</p> <p>With chapters written by over fifty leading experts in their fields, <i>Enzyme Inhibition in Drug Discovery and Development</i> fosters a cross-fertilization of pharmacology, drug metabolism, pharmacokinetics, and toxicology by understanding the “good” inhibitions—desirable pharmacological effects—and “bad” inhibitions—drug–drug interactions and toxicity. The book discusses:</p> <ul> <li> <p>The drug discovery process, including drug discovery strategy, medicinal chemistry, analytical chemistry, drug metabolism, pharmacokinetics, and safety biomarker assessment</p> </li> <li> <p>The manipulations of drug metabolizing enzymes and transporters as well as the negative consequences, such as drug–drug interactions</p> </li> <li> <p>The inhibition of several major drug target pathways, such as the GPCR pathway, the NFkB pathway, and the ion channel pathway</p> </li> </ul> <p>Through this focused, single-source reference on the fundamentals of drug discovery and development, researchers in drug metabolism and pharmacokinetics (DMPK) will learn and appreciate target biology in drug discovery; discovery biologists and medicinal chemists will also broaden their understanding of DMPK.</p>

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