Handbook of LC-MS Bioanalysis

<p><b>Consolidates the information LC-MS bioanalytical scientists need to analyze small molecules and macromolecules</b></p> <p>The field of bioanalysis has advanced rapidly, propelled by new approaches for developing bioanalytical methods, new liquid chromatographic (LC) techniques, and new mass spectrometric (MS) instruments. Moreover, there are a host of guidelines and regulations designed to ensure the quality of bioanalytical results.</p> <p>Presenting the best practices, experimental protocols, and the latest understanding of regulations, this book offers a comprehensive review of LC-MS bioanalysis of small molecules and macromolecules. It not only addresses the needs of bioanalytical scientists working on routine projects, but also explores advanced and emerging technologies such as high-resolution mass spectrometry and dried blood spot microsampling.</p> <p><i>Handbook of LC-MS Bioanalysis</i> features contributions from an international team of leading bioanalytical scientists. Their contributions reflect a review of the latest findings, practices, and regulations as well as their own firsthand analytical laboratory experience. The book thoroughly examines:</p> <ul> <li>Fundamentals of LC-MS bioanalysis in drug discovery, drug development, and therapeutic drug monitoring</li> <li>The current understanding of regulations governing LC-MS bioanalysis</li> <li>Best practices and detailed technical instructions for LC-MS bioanalysis method development, validation, and stability assessment of analyte(s) of interest</li> <li>Experimental guidelines and protocols for quantitative LC-MS bioanalysis of challenging molecules, including pro-drugs, acyl glucuronides, N-oxides, reactive compounds, and photosensitive and autooxidative compounds</li> </ul> <p>With its focus on current bioanalytical practice, <i>Handbook of LC-MS Bioanalysis</i> enables bioanalytical scientists to develop and validate robust LC-MS assay methods, all in compliance with current regulations and standards.</p>