Nuclear Organization in Development and Disease

This book draws together contributions from cell and developmental biologists, structural biologists, geneticists and clinical scientists aimed at a better understanding of the cellular and molecular basis of these diseases. Topics include: <ul> <li>How nuclear structure and location within a nucleus affect gene expression</li> <li>Chromatin organization and cell differentiation</li> <li>The nature of the interactions between the nuclear envelope and the cytoskeleton</li> <li>The extent to which the cytoskeleton mediates communication between the cell membrane and nucleus in regulating gene expression and whether disruption of such communication might underlie the disease processes</li> </ul> <p>It is hoped that a better understanding of the mechanisms leading to disease pathogenesis may ultimately lead to more rational and appropriate treatments.</p>