Oral Bioavailability Assessment

10,671.00

Basics and Strategies for Drug Discovery and Development

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Specifically geared to personnel in the pharmaceutical and biotechnology industries, this book describes the basics and challenges of oral bioavailability – one of the most significant hurdles in drug discovery and development.<br /><br />•    Describes approaches to assess pharmacokinetics and how drug efflux and uptake transporters impact oral bioavailability<br />•    Helps readers reduce the failure rate of drug candidates when transitioning from the bench to the clinic during development<br />•    Explains how preclinical animal models – used in preclinical testing – and in vitro tools translate to humans, which is an underappreciated and complicated area of drug development<br />•    Includes chapters about pharmacokinetic  modelling, the Biopharmaceutics Drug Disposition Classification System (BDDCS), and the Extended Clearance Classification System (ECCS)<br />•    Has tutorials for applying strategies to medicinal chemistry practices of drug discovery/development