Silicon-mediated Transformations of Functional Groups

In the first work to comprehensively cover this all-important topic, the recognized expert Helmut Vorbruggen provides both organic and bioorganic chemists with much new and valuable information for preparative synthesis. <br> Although every organic chemist may be familiar with different aspects of silylation for the protection of functional groups, this book covers the concept of protection while simultaneously silylating-activating various functional groups, such as amides and ureas. This novel methodology opens thus numerous synthetic pathways<br> while effecting the elimination of water in it volatile persilylated form under rather mild reaction conditions, which are often advantageous compared to conventional methods.<br> The compact form and clear structure of this monograph make this a long-awaited ready reference.<br> <br> From the contents:<br> <br> Introduction<br> * Techniques of Preparative Silylations-Desilylations<br> * Preparation and Properties of Siliconoxy-Leaving Groups<br> * Reactions of Free and Derivatized Carboxylic Acids and Carbon Dioxide<br> * Reactions of Aldehydes and Ketones<br> * Reactions of Alcohols, Ethers and Epoxides<br> * Reaction of N-O Systems<br> * Reactions of S-O and Se-O Systems<br> * Cyclizations and Ring Enlargements<br> * Base and Acid-Catalyzed as well as Thermal Eliminations of Trimethylsilanol. Peterson Reactions<br> * Formation of Carbon-Phosphorous Double- and Triple Bonds<br> * Reductions and Oxidations<br> * Dehydration-Activation as well as Silylation of Inorganic and Organic Salts and Metalorganic Compounds <br> * Formation of Polymers