Structural Biology in Drug Discovery

<p>With the most comprehensive and up-to-date overview of structure-based drug discovery covering both experimental and computational approaches, <i>Structural Biology in Drug Discovery: Methods, Techniques, and Practices</i> describes principles, methods, applications, and emerging paradigms of structural biology as a tool for more efficient drug development. Coverage includes successful examples, academic and industry insights, novel concepts, and advances in a rapidly evolving field.<br /><br />The combined chapters, by authors writing from the frontlines of structural biology and drug discovery, give readers a valuable reference and resource that:</p> <ul> <li>Presents the benefits, limitations, and potentiality of major techniques in the field such as X-ray crystallography, NMR, neutron crystallography, cryo-EM, mass spectrometry and other biophysical techniques, and computational structural biology</li> <li>Includes detailed chapters on druggability, allostery, complementary use of thermodynamic and kinetic information, and powerful approaches such as structural chemogenomics and fragment-based drug design</li> <li>Emphasizes the need for the in-depth biophysical characterization of protein targets as well as of therapeutic proteins, and for a thorough quality assessment of experimental structures</li> <li>Illustrates advances in the field of established therapeutic targets like kinases, serine proteinases, GPCRs, and epigenetic proteins, and of more challenging ones like protein-protein interactions and intrinsically disordered proteins</li> </ul>